Involvement of Thyroid Hormone and Its α Receptor in Avian Neurulation

Thyroid hormone receptor-α and vascular function.

Thyroid hormone (TH) treatment exerts beneficial effects on the cardiovascular system: it lowers cholesterol and LDL levels and enhances cardiac contractile function. However, little is known about the effect of TH on vascular function or the functional role of TH receptors (TRs) in the regulation of vascular tone. We have investigated the contribution of TRs to vascular contractility in the he...

Crossing the hurdles of thyroid hormone receptor-α activation.

Thyroid hormone acts in virtually every biological system in vertebrates by controlling the expression of different sets of genes. To achieve this, thyroid hormone interacts with two receptors (TR), TR and TR , located in the nucleus of its target cells, which turn gene transcription on or offand thusmediate thebiological effectsassociatedwith the thyroid secretion (1, 2). The distribution of T...

Thyroid hormone receptor-α deletion decreases heart function

6 7 Kiao Ling Liu , Laurence Canaple , Peggy del Carmine , 8 Karine Gauthier , Michel Beylot , Ming Lo 9 10 11 12 a Neurocardiology Unit EA 4612, Institute of Pharmaceutical and Biological Sciences, 13 University Claude Bernard Lyon 1, France 14 b Institute of Functional Genomics of Lyon, University Claude Bernard Lyon 1, Centre 15 National de la Recherche Scientifique, Ecole Normale Supérieure...

Comparison of Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variant 1 in Different Stages of Endometriosis

Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α.

Genetic evidence from patients with mutations of the thyroid hormone receptor α gene (THRA) indicates that the dominant negative activity of mutants underlies the pathological manifestations. However, the molecular mechanisms by which TRα1 mutants exert dominant negative activity in vivo are not clear. We tested the hypothesis that the severe hypothyroidism in patients with THRA mutations is du...